Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Thymotrinan trifluoroacetate | 00-00-0 | 98.7% | 531.48 g·mol⁻¹ | C18H32F3N7O8 | 25 MG
Thymotrinan TFA is a biologically active fragment of the thymus hormone thymopoietin, provided as the trifluoroacetate (TFA) salt for research use. It modulates immune responses, affecting both humoral and cellular immunity, and is supplied as a purified synthetic peptide for laboratory studies.
- Immunomodulating peptide that affects humoral and cellular responses.
- Supplied as the trifluoroacetate salt for improved stability and handling.
- High purity suitable for in vitro and preclinical research.
- Available in small-scale quantities for peptide research workflows.
- Molecular weight 531.48 g·mol⁻¹; formula C18H32F3N7O8.
Medchemexpress LLC 6bK (TFA) | 1774353-12-6 | MFCD30182289 | 99.4% | 871.94 g/mol | C43H56F3N7O9 | 5 MG
6bK TFA is a potent, selective insulin-degrading enzyme (IDE) inhibitor used in preclinical research to study insulin metabolism and glucose tolerance. It shows an in vitro IC50 of approximately 50 nM and has been reported to increase circulating insulin and improve oral glucose tolerance in high-fat-fed mice.
- Potent IDE inhibition (IC50 ≈ 50 nM).
- Selective activity for insulin-degrading enzyme.
- High purity (≈99.4%).
- Available as solid and DMSO solution in multiple pack sizes.
- Supplied with analytical documents (COA, HPLC, LCMS).
- Recommended storage: solid -20°C; in solvent -80°C (6 months) or -20°C (1 month).
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo100G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo100G
Apexbio Technology LLC Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) 10x(1ml A 1ml B)
Under stable environmental conditions endogenous protein synthesis and degradation are balanced thus maintaining stable cellular protein levels Cell crude extracts contain numerous endogenous enzymes such as phosphatases and proteases that can degrade proteins in the extracts During in vitro protein extraction from cells and tissues protein synthesis practically ceases while protein degradation increases The optimal way to enhance yields of intact proteins is to add inhibitors for these known enzymes The Protease Inhibitor Cocktail for bacterial cell extracts (100X in DMSO) is designed for bacterial extracts to enhance the stability of proteins This cocktail inhibits proteases responsible for degrading non-phosphorylated or phosphorylated protein substrates This Protease Inhibitor Cocktail is provided as a ready-to-use solution and it is formulated in DMSO
Apexbio Technology LLC 2X hyperfusion plus master mix 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Hyperfusion Plus DNA Polymerase exhibits both 5 to 3 polymerase activity and 3 to 5 exonuclease (proofreading) activity producing blunt-ended amplification products rather than A-tailed ends (commonly produced by Taq polymerase) Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb
TARGETMOL CHEMICALS INC LEVOROTATION NIMORAZOLE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Levorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.
TARGETMOL CHEMICALS INC 6H05 TFA 5MG
Also available in 1mg 2mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. 6H05 TFA (6H05 trifluoroacetate) is a selective and allosteric oncogenic mutant K-Ras(G12C) inhibitor. purity: 98%
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 25G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 25G
TARGETMOL CHEMICALS INC Elarofiban TFA 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease. Purity 100%
![eMolecules 1810069-99-8 | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | MFCD29037458 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502158414.JPG-250.jpg)
eMolecules 1810069-99-8 | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | MFCD29037458 | 1g
Medchem Express | Azosemide | 10mg | 495799592 | HY-107321 | 27589-33-9 | MFCD00867321 | 370.830 | C12H11ClN6O2S2
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Medchemexpress LLC 6H05 trifluoroacetate | 2061344-88-3 | 99.0% | 590.14 | C22H31ClF3N3O4S3 | 1MG
6H05 TFA is the trifluoroacetate salt of 6H05, a selective, allosteric inhibitor of the oncogenic mutant K-Ras(G12C) intended for biochemical and cellular research. Supplied as a solid or as a 10 mM DMSO solution, the compound is provided at high purity for assay development and mechanistic studies.
- Selective, allosteric inhibitor of K-Ras(G12C).
- High purity (99.02%).
- Molecular formula C22H31ClF3N3O4S3; molecular weight 590.14.
- Available in small-scale solid quantities and as a 10 mM DMSO solution.
- Suitable for biochemical and cellular assays; for research use only, not for human use.
Medchemexpress LLC MI-1061 TFA | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 10MM 1ML
MI-1061 TFA is the trifluoroacetate salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 interaction (reported IC50 = 4.4 nM; Ki = 0.16 nM). The compound is offered as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL) for in vitro assays, and the manufacturer provides solubility and in vivo formulation guidance. Typical uses include biochemical and cell-based studies of p53 pathway modulation.
- Potent MDM2-p53 interaction inhibitor (IC50 4.4 nM).
- Available as solid and as a 10 mM solution in DMSO for immediate use.
- High purity (approximately 97.5%), suitable for research assays.
- Soluble in DMSO (reported solubility 120 mg/mL), enabling concentrated stocks.
- Manufacturer provides recommended stock concentrations and in vivo vehicle guidance.
Medchemexpress LLC Mi-1061 Tfa | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 25MG
MI-1061 TFA is the trifluoroacetate (TFA) salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 protein-protein interaction. It activates p53, induces apoptosis in tumor models, and shows selective activity in p53 wild-type cell lines.
- Potent biochemical MDM2-p53 interaction inhibitor (IC50 = 4.4 nM; Ki = 0.16 nM).
- Selective cellular activity with IC50 = 100 nM in SJSA-1 and 250 nM in HCT-116 p53+/+; >10,000 nM in p53-/- cells.
- Trifluoroacetate salt presented as a solid form.
- Molecular weight 696.47 and molecular formula C32H27Cl2F4N3O6.
- Intended for research use as a tool compound to study p53 activation and antitumor effects.
- Purity listed as 97.47%.
Medchemexpress LLC Cl2e-SN38 TFA | 99.1% | 1855.95 | C89H117F3N14O26 | 5 MG
CL2E-SN-38 TFA is an antibody-drug conjugate (ADC) drug-linker consisting of an SN-38 payload attached via a CL2E linker in the trifluoroacetate (TFA) salt form. It is intended for preclinical research into ADCs, where SN-38 functions as a topoisomerase I inhibitor.
- Highly releasable and structurally stable antibody-SN-38 conjugate.
- Contains SN-38 payload, a topoisomerase I inhibitor.
- TFA salt form for improved solubility and handling.
- Available in small research quantities (5 MG).
- High purity suitable for preclinical ADC development.